howMed Know Yourself
| Ergotamine | Ergometrine |
| Peptide alkaloid | Amine alkaloid |
| Polypeptide chain present | Polypeptide chain absent |
| Powerful antagonist on alpha receptor and partial agonist | Mild agonist on alpha receptor |
| No effect on dopamine receptor | Mild effect on dopamine receptor |
| Partial agonist on serotonin receptor | Partial agonist and antagonist on serotonin receptors |
| Less effect on uterus | More effect on uterus |
| Blood vessels
Endothelial damage Potent vasoconstriction |
No damage Less vasoconstriction |
| Miosis (alpha blocked) | Mydriasis (alpha agonist) |
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